APLICAÇÕES DE NANOPARTÍCULAS POLIMÉRICAS NA DOENÇA DE ALZHEIMER: AVANÇOS, DESAFIOS E PERSPECTIVAS
DOI:
https://doi.org/10.22407/1984-5693.2025.v17.p.20251702Resumo
A Doença de Alzheimer (DA) é um dos desafios mais complexos da saúde pública global, afetando milhões de pessoas e caracterizando-se por um declínio progressivo na memória e nas funções cognitivas. Apesar de avanços na compreensão de sua fisiopatologia, as terapias disponíveis ainda têm eficácia limitada, em grande parte devido à barreira hematoencefálica, que dificulta a administração de fármacos diretamente no cérebro. Nesse contexto, as nanopartículas poliméricas emergem como uma estratégia promissora, com propriedades como biocompatibilidade, biodegradabilidade e capacidade de encapsular medicamentos, permitindo que atravessem essa barreira e realizem uma liberação controlada e sustentada de fármacos. Este estudo revisa as potenciais aplicações dessas nanopartículas na DA, destacando avanços como o uso de polímeros que aumentam a estabilidade e a eficácia dos compostos encapsulados. A pesquisa oferece uma visão abrangente sobre o papel transformador dessas tecnologias na busca por terapias mais eficazes e personalizadas para a DA.
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