APPROACHING ALOPECIA TREATMENT VIA POLYMERIC NANOPARTICLES: A BRIEF OVERVIEW: Perspectivas de tratamento da alopécia usando nanopartículas poliméricas: um breve resumo

Gabriela dos Santos David Ribeiro; Anne Caroline da Silva Rocha; Lívia Rodrigues de Menezes

doi:10.22407/1984-5693.2024.v16.p.e20241612

Autores

Gabriela dos Santos David Ribeiro 1- Universidade Federal do Rio de Janeiro - Instituto de Macromoléculas Professora Eloisa Mano
Anne Caroline da Silva Rocha 2- Universidade Federal do Rio de Janeiro – Centro de Tecnologia Mineral CETEM, Av. Pedro Calmon, 900. CEP 21941-908, Ilha do Fundão, RJ
Lívia Rodrigues de Menezes Universidade Federal do Rio de Janeiro - Instituto de Macromoléculas Professora Eloisa Mano

DOI:

https://doi.org/10.22407/1984-5693.2024.v16.p.e20241612

Resumo

Hair loss is a reality that plagues many people. One of the most common causes of hair loss today is androgenic alopecia, which is a progressive miniaturization of the follicle. After the COVID-19 pandemic, cases of alopecia had a sharp increase in the number of registered cases, indicating that an infection caused by the SARS-CoV-2 virus possibly stimulated a hair loss due to the stress caused by the infection, modification in the immune system and the emergence of microthrombi in the region of the hair follicle. There are some medicines in the market with drugs of international knowledge, such as minoxidil, finasteride and spirinolactone, which are already used for the treatment of alopecia. However, these drugs have difficulties in reaching the hair follicles, therefore, the delivery of drugs in polymeric nanoparticles has been shown to be a promising strategy, with greater efficiency in the vectorization of these assets into the interior of the hair follicles, thus promoting greater effectiveness in the treatment of the pathology in question.

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